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April 11, 2026Molecular Nutrition & Food ResearchOpen Access

Determination of Folate Bioavailability From Brewer's Yeast in a Dual Isotope Randomized Human Intervention Study

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Authors

NWNadine WeberLSLisa StriegelYMYvonne Methner

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Overview

Pilot study assesses folate bioavailability in volunteers using brewer's yeast, suggesting new measurement methods.

Key Points

  • The aim is to evaluate the bioavailability of folate from brewer's yeast using a dual isotope approach.
  • Conducted a dual isotope randomized human intervention study with 6 volunteers.
  • Administered intrinsically N-15-labeled brewer's yeast and C-13-labeled folate as reference.
  • Collected 21 plasma samples on study days to analyze isotopologues of folate.
  • Achieved a mean bioavailability of 74% for yeast folate compared to the reference folate.
  • Demonstrated that intrinsically labeled foods are effective for measuring the bioavailability of natural folates.

Cite This Study

Weber et al. (2026) studied this question.

synapsesocial.com/papers/69d9e5b378050d08c1b75ecbhttps://doi.org/10.1002/mnfr.70453
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1High Bioavailability of Spinach Folate Evaluated by Functional Biomarkers in a Folate Depletion-Repletion Mouse Model2024
  2. 2Impact of carbon and nitrogen source variation on B-vitamin accumulation in Yarrowia lipolytica: Toward microbial fortification of food ingredients2026
  3. 3Improving FolateBioaccessibility and Modulating GutMicrobiota Profile with Folate-Enriched Purple Cabbage Juice by Optimized <i>Lactiplantibacillus plantarum</i> Fermentation2026
  4. 4Pharmacokinetics of (6S)-5-Methyltetrahydrofolate dicholine salt compared to folic acid: a randomized double-blind single dose cross-over study2025
  5. 5A Comprehensive Review of Fortification, Bioavailability, and Health Benefits of Folate2025 · 16 citations