During preparative-scale reductions of cyclic ketone and aldehyde substrates of horse liver alcohol dehydrogenase, up to 105-fold recycling of catalytic amounts of coenzyme has been achieved by in situ regeneration of NADH with sodium dithionite; the results indicate that >70% yields of the corresponding alcohols will be obtained provided the rate of reduction of a carbonyl compound is not less than 0·01 times that of cyclohexanone.
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Jones et al. (1972) studied this question.