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July 14, 2009Anesthesia & Analgesia

Differences in Production of Reactive Oxygen Species and Mitochondrial Uncoupling as Events in the Preconditioning Signaling Cascade Between Desflurane and Sevoflurane

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Authors

FSFilip SedlićUniversity of ZagrebDPDanijel PravdićUniversity Clinical Hospital MostarMLMarko LjubkovićUniversity of Split

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Implication

Experimental study reveals differential ROS production and mitochondrial uncoupling in rat cardiomyocytes, indicating desflurane stimulates stronger cardioprotective signaling than sevoflurane.

Key Points

  • To determine the role of reactive oxygen species and mitochondrial uncoupling in cardioprotective preconditioning mediated by desflurane compared with sevoflurane.
  • Assessed isolated rat cardiomyocytes exposed to desflurane or sevoflurane preconditioning before exposure to oxidative stress-induced injury.
  • Applied ROS scavenging to evaluate its effect on cell survival and anesthetic-induced mitochondrial uncoupling.
  • Both desflurane and sevoflurane preconditioning protected isolated rat cardiomyocytes against cell death caused by oxidative stress.
  • Scavenging ROS abolished anesthetic preconditioning and attenuated mitochondrial uncoupling, confirming ROS act upstream in the signaling cascade.
  • Desflurane induced a greater stimulation of ROS production and subsequent mitochondrial uncoupling than sevoflurane.

Cite This Study

Sedlić et al. (2009) studied this question.

synapsesocial.com/papers/69dc321bd50c49528a9f53f1https://doi.org/10.1213/ane.0b013e3181a93ad9
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