What question did this study set out to answer?

To introduce the Codon Adaptation Index (CAI) as a simple and effective measure of directional synonymous codon usage bias.

January 1, 1987Nucleic Acids ResearchOpen Access

The codon adaptation index-a measure of directional synonymous codon usage bias, and its potential applications

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Authors

PSPaul M. SharpRutgers, The State University of New Jersey WLWen‐Hsiung LiSouth China Agricultural University

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Implication

Methodological analysis demonstrates a metric for synonymous codon usage bias across genes, highlighting applications in predicting expression levels and viral host adaptation.

Key Points

To introduce the Codon Adaptation Index (CAI) as a simple and effective measure of directional synonymous codon usage bias.
Assessed codon fitness using a reference set of highly expressed genes from a target species.
Calculated gene-level adaptation scores based on the relative frequencies of all codons present within the target gene sequence.
Established that the index measures the degree to which natural selection shapes synonymous codon usage patterns.
Demonstrated utility for predicting gene expression levels, comparing codon usage across distinct taxa, assessing viral adaptation to hosts, and evaluating heterologous gene expression.

Cite This Study

Sharp et al. (1987) studied this question.

synapsesocial.com/papers/69dcc40e89c4deb67d359a52 https://doi.org/10.1093/nar/15.3.1281

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January 1, 1987Nucleic Acids ResearchOpen Access

The codon adaptation index-a measure of directional synonymous codon usage bias, and its potential applications

View Full Paper

Ask AI

Bookmark

Authors

PSPaul M. SharpRutgers, The State University of New Jersey WLWen‐Hsiung LiSouth China Agricultural University

Discussion

Member takes

Implication

Methodological analysis demonstrates a metric for synonymous codon usage bias across genes, highlighting applications in predicting expression levels and viral host adaptation.

Key Points

To introduce the Codon Adaptation Index (CAI) as a simple and effective measure of directional synonymous codon usage bias.
Assessed codon fitness using a reference set of highly expressed genes from a target species.
Calculated gene-level adaptation scores based on the relative frequencies of all codons present within the target gene sequence.
Established that the index measures the degree to which natural selection shapes synonymous codon usage patterns.
Demonstrated utility for predicting gene expression levels, comparing codon usage across distinct taxa, assessing viral adaptation to hosts, and evaluating heterologous gene expression.

Cite This Study

Sharp et al. (1987) studied this question.

synapsesocial.com/papers/69dcc40e89c4deb67d359a52 https://doi.org/10.1093/nar/15.3.1281

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