April 1, 1991British journal of surgery
Predictors of death from aortic aneurysm among middle-aged men: The Whitehall study
Why the study?
What are the predictors of death from aortic aneurysm among middle-aged men?
Population
18,403 male civil servants examined at age 40-64 years, including 99 cases of fatal aortic aneurysm matched…
Comparison
Risk factors including smoking and diastolic… vs Lifelong non-smokers; lower diastolic blood…
Design
Case-control
Follow-up
18 years
Authors
Discussion
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Member takes
Implication
May warrant smoking cessation and BP control in middle-aged men; leaves open confirmation in prospective cohorts.
Structured PICO
What are the predictors of death from aortic aneurysm among middle-aged men?
P
Population
18,403 male civil servants examined at age 40-64 years (Whitehall study), including 99 cases of fatal aortic aneurysm matched by age to 10 controls each
I
Intervention
Risk factors including smoking (manufactured cigarettes, pipe/cigars, hand-rolled cigarettes) and diastolic blood pressure
C
Comparator
Lifelong non-smokers; lower diastolic blood pressure
O
Outcome
Death attributed to aortic aneurysmhard clinical
Hypertension and smoking, particularly of hand-rolled cigarettes, are major and potentially remediable risk factors for fatal aortic aneurysm in middle-aged men.
Cite This Study
David P. Strachan (1991) studied this question.