Why the study?
Does Tumor Necrosis Factor (TNF) antagonist therapy induce new-onset heart failure or exacerbate existing disease in patients?
Does Tumor Necrosis Factor (TNF) antagonist therapy induce new-onset heart failure or exacerbate existing disease in patients?
TNF antagonists may carry a risk of inducing or exacerbating heart failure.
May warrant heart failure vigilance with TNF antagonists; hypothesis-generating from Level 5 evidence and requires prospective confirmation.
In a fraction of patients, TNF antagonists might induce new-onset heart failure or exacerbate existing disease.
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Kwon et al. (2003) studied this question.
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