Do biomarker profiles (osteopontin, neuropilin) predict outcomes differently in HFpEF compared to HFrEF?
Biomarker profiles differ between HFpEF and HFrEF, with osteopontin and neuropilin predicting outcomes specifically in HFpEF.
In HFpEF, inflammation and angiogenesis-mediated interactions are predominantly observed, while stretch-mediated interactions are found in HFrEF. The remodeling marker osteopontin and the angiogenesis marker neuropilin predicted outcome in HFpEF, but not in HFrEF.
Tromp et al. (Fri,) studied this question.