Why the study?
Do different ACE inhibitor treatments with varying peripheral blockade affect sympathetic activity and remodeling differently in rats after myocardial infarction?
Do different ACE inhibitor treatments with varying peripheral blockade affect sympathetic activity and remodeling differently in rats after myocardial infarction?
Central and peripheral ACE-mediated mechanisms may be sequential, resulting in similar effects on remodeling and sympathetic activity regardless of the extent of peripheral ACE blockade in post-MI rats.
Answers are grounded in this paper and cite their sources.
Animal data on ACE inhibitors post-MI should not alter clinical practice; leaves open sequential central-peripheral mechanisms in remodeling.
Despite marked differences in the extent of peripheral blockade, all three treatments similarly affected sympathetic activity and decreased cardiac Ang II, preload and remodeling after MI. One may speculate that central and peripheral ACE-mediated mechanisms are sequential and therefore only minor additional effects of peripheral ACE blockade are noted.
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Ahmad et al. (2008) studied this question.
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