February 12, 2004Biochemistry

Functional Role of Loop 2 in Myosin V

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Population

Monomeric myosin V containing a single IQ domain (MV 1IQ)

Comparison

Mutation of loop 2 vs Wild-type myosin V

Design

Preclinical

Authors

CYChristopher M. YengoPennsylvania State University HSH. Lee SweeneyHeart Failure & Transplant

Discussion

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Implication

Hypothesis-generating for myosin processivity; leaves open relevance to cardiac myosins in vivo.

Structured PICO

Population

Monomeric myosin V containing a single IQ domain (MV 1IQ)

Intervention

Mutation of loop 2 (a surface loop in the actin-binding region)

Comparator

Wild-type myosin V

Outcome

Actin affinity (K(ATPase)) and maximum ATPase rate (V(MAX))surrogate

Loop 2 in myosin V is critical for maintaining high affinity for actin in weak binding states, which may prevent diffusion away from the actin filament and enhance processive motion.

Cite This Study

Yengo et al. (2004) studied this question.

synapsesocial.com/papers/69df13cdb8d7e945666145a3 https://doi.org/10.1021/bi035510v

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Functional Role of Loop 2 in Myosin V

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Functional Role of Loop 2 in Myosin V

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider