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April 15, 2026Analytical Chemistry

Quantitatively Sensing Lipid Droplets Polarity in Cells and Atherosclerotic Model with a Novel Naphthalimide-Based Fluorescent Probe

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Authors

RLRui LiRZRi ZhouWSWei Shi

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Overview

Quantitative analysis of lipid droplets polarity in atherosclerosis, indicating diagnostic potential for plaque detection.

Key Points

  • This research aims to develop a novel fluorescent probe to quantify the polarity of lipid droplets, particularly in the context of atherosclerosis.
  • Development of the naphthalimide-based probe Lipi-NIFD
  • Use of hyperspectral fluorescence imaging (HSFI) to detect polarity changes
  • Application of the probe in aorta, liver, and AS plaque of model mice
  • Lipi-NIFD shows high fluorescence quantum yield and polarity sensitivity
  • Quantitative mapping reveals significantly lower LDs polarity in AS plaque compared to aorta
  • LDs polarity in AS plaque is substantially lower (E_T(30) = 32.90 kcal mol^-1) than in major aorta region (E_T(30) = 33.89 kcal mol^-1)

Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/69df2bece4eeef8a2a6b0e32https://doi.org/10.1021/acs.analchem.6c00280
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Modification of an AIE Fluorescent Probe for Monitoring the Polarity of Lipid Droplets Based on a series of Synthesized Aryl Naphthalizes2024 · 9 citations
  2. 2A lipid droplet‐selective fluorescent probe for real‐time imaging and polarity sensing2025 · 8 citations
  3. 3BODIPY-Based Fluorescent Probes Distinguish the Heterogeneity of Lipid Droplets in Carotid and Femoral Atherosclerotic Plaques2025 · 4 citations
  4. 4Polarity-triggered high-contrast fluorescent imaging of lipid droplets via a naphthalimide fluorophore2026
  5. 5Lipid droplet-targeted near-infrared fluorescent probes for polarity detection and identification of non-alcoholic fatty liver disease2025 · 3 citations