Key result
More metabolic syndrome components link to higher LVM, largely explained by age, sex, and BMI.
Why the study?
Metabolic syndrome comprises coexisting risk factors increasing cardiovascular disease risk, but the correlation between the number of its components and subclinical cardiac dysfunction in individuals without overt cardiovascular disease needed investigation.
Does the number of metabolic syndrome components correlate with subclinical cardiac dysfunction in individuals without overt CVD?
Observational (n=100)
No
Does the number of metabolic syndrome components correlate with subclinical cardiac dysfunction in individuals without overt CVD?
p-value: p=<0.001
The number of metabolic syndrome components correlates with subclinical cardiac dysfunction on echocardiography, but this association is largely explained by age, sex, and BMI.
Account for age, sex, and BMI rather than MetS count in subclinical dysfunction; leaves open direct cardiometabolic effects for prospective study.
Background: Metabolic syndrome (MetS) comprises coexisting risk factors enhancing the likelihood of developing cardiovascular disease (CVD). The aim of this study was to investigate the correlation between the number of MetS components and subclinical cardiac dysfunction, assessed via transthoracic echocardiography (TTE), in individuals without overt CVD. Methods: A retrospective analysis was performed using data from 100 patients (63% female; mean age 58.8 ± 16.81 years) hospitalized in the Department of Internal Medicine, Angiology and Physical Medicine at the Medical University of Silesia in Katowice, Poland, between June 2022 and February 2024. The inclusion criteria were the absence of diagnosed atherosclerotic CVD and no evidence of acute illness or exacerbation of chronic diseases. Each participant was evaluated for MetS components and underwent TTE. Results: Univariate analysis revealed significant correlations between the number of MetS components and selected TTE parameters, including left ventricular mass (LVM) (R = 0.406; p < 0.001), left ventricular mass index (LVMI) (R = 0.248; p = 0.013), left ventricular ejection fraction (LV EF) (R = −0.261; p = 0.009), left atrial volume (LAV) (R = 0.312; p < 0.001), and left atrial volume index (LAVI) (R = 0.273; p = 0.007). These correlations did not remain significant after adjusting for age, sex, and body mass index (BMI). Among patients not meeting the full diagnostic criteria for MetS, LAV and LAVI values remained significantly correlated with the number of MetS components, independent of confounding variables. Conclusions: The selected echocardiographic parameters were significantly correlated with the number of MetS components; however, most associations were explained by age, sex, and BMI.
No takes yet. Share an insight, caveat, or question.
Starzak et al. (2026) conducted an observational in Metabolic syndrome (n=100). Number of Metabolic Syndrome components was evaluated on Correlation between the number of MetS components and subclinical cardiac dysfunction assessed via TTE (p=<0.001). The number of metabolic syndrome components correlated with left ventricular mass (R=0.406, p<0.001) and other TTE parameters, but most associations were explained by age, sex, and BMI.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: