Key result
Metabolic syndrome is linked to subclinical LV dysfunction, worsening myocardial performance index by ~17%.
Why the study?
The impact of metabolic syndrome on left ventricular function and structure remains incompletely defined.
Cross-Sectional (n=60)
No
Metabolic syndrome is associated with subclinical left ventricular diastolic and systolic dysfunction, increased left ventricular mass, and concentric remodeling even when ejection fraction is preserved.
Answers are grounded in this paper and cite their sources.
Metabolic syndrome may warrant closer cardiac surveillance; leaves open whether early intervention alters progression in prospective studies.
Background: MetS is a cluster of cardiovascular risk factors related with rose mortality and morbidity. Its impact on heart function and structure, particularly left ventricular (LV) performance, remains incompletely defined. Objective: To assess LV functional and structural changes in cases with MetS using transthoracic echocardiography and tissue Doppler imaging (TDI). Methods: This research involved 60 cases. All of them underwent echocardiographic assessment at Echocardiography Unit, Al-Azhar University Hospital (Assiut), Those cases have been categorized into three groups: Control Group(A): twenty persons with absent (0) any criteria of metabolic syndrome. Study Group(B): 20 persons with pre-metabolic syndrome (1-2 criteria). Study Group(C): 20 persons with metabolic syndrome (≥3 criteria). Results: left ventricular systolic function by ejection fraction has been preserved across all groups. However, MPI by PWD and TDI was significantly greater in MetS patients (0.48±0.08 and 0.55±0.12, correspondingly) in comparison with controls (0.41±0.02 and 0.47±0.02; p<0.001). S’ velocity was reduced in MetS (9.3±2.08 cm/s) compared with controls (12.4±1.46 cm/s; p<0.0001). Diastolic function parameters were impaired in MetS, with lower E/A ratio (0.83±0.20 vs. 1.35±0.13, p<0.0001), higher E/E′ (13.29±3.92 vs. 5.32±1.09, p<0.0001), and prolonged IVRT (100.55±24.91 ms vs. 74.65±4.91 ms, p<0.0001). LVMI/Ht^2.7 and RWT were significantly elevated in MetS than controls, indicating hypertrophy and concentric remodeling. Conclusion: MetS is related to subclinical LV diastolic & systolic dysfunction, increased LV mass, and concentric remodeling despite preserved ejection fraction. Echocardiography with TDI provides sensitive detection of early myocardial impairment in these cases.
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Mahmoud Ahmed Abdelghafar, Waleed Yousof, Ahmed El Tayeb, Mahmoud M. Ibrahim, Mohamed Khedrawy, Tarek A. H. Bakr, Waleed S. El-Nasser, Wael Esmat Ali, Hamada H. Hassan, Wael Shaibat Alhamd Mohamed (2025) conducted a cross-sectional in Metabolic syndrome (n=60). Metabolic syndrome vs. Healthy controls (0 criteria of metabolic syndrome) was evaluated on Myocardial performance index (MPI) by tissue Doppler imaging (TDI) (p=<0.0001). Metabolic syndrome is associated with subclinical left ventricular dysfunction, demonstrated by a higher myocardial performance index by tissue Doppler imaging compared to healthy controls.
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