Key result
Metabolic syndrome was associated with significantly increased left ventricular diameter in systole compared to controls (HR 1.29; 95% CI 1.13-1.46; p<0.001).
Why the study?
The outcome of metabolic syndrome depends on structural cardiac changes, prompting evaluation of echocardiography abnormalities in this population.
Does metabolic syndrome affect cardiac structure and function as measured by echocardiography?
Cross-Sectional (n=150)
Does metabolic syndrome affect cardiac structure and function as measured by echocardiography?
Hazard Ratio: 1.29 (95% CI 1.13–1.46)
p-value: p=<0.001
Metabolic syndrome is associated with significant structural cardiac changes, including increased left ventricular mass and left atrial volume, highlighting the need for early lifestyle modifications.
LV systolic diameter link to metabolic syndrome is hypothesis-generating; prospective studies needed before any clinical application.
OBJECTIVES: Metabolic syndrome (MS) is a collection of metabolic disorders including hyperglycemia, hypertension and dyslipidemia. The outcome of metabolic syndrome depends on structural changes in heart like increased left atrial size or increased left ventricular mass. This study was done to determine the echocardiography abnormalities in metabolic syndrome. METHODS: After obtaining informed consent, 75 subjects with metabolic syndrome and 75 controls were included in the study. 2D echo/M mode examination was performed for all. Aortic root, left atrial size, left atrial volume, septal wall thickness during systole (SWs) and diastole (SWd), posterior wall thickness during systole (PWs) and diastole (PWd), left ventricle dimension during systole (LVDs) and diastole (LVDd), and ejection fraction were measured. The values were compared between the groups. RESULTS: After adjustment for age, sex, smoking, alcohol and BMI; left ventricular diameter in systole and diastole was significantly more than controls (p<0.001); HR of 1.29 (95% CI 1.13-1.46), 1.29 (95% CI 1.15-1.45) respectively. Left ventricular mass and left atrial volume were increased significantly in subjects with metabolic syndrome (p<0.001); HR were 1.06 (95% CI 1.03-1.08), 1.13 (95% CI 1.06-1.19) respectively. Ejection fraction was low normal in subjects with metabolic syndrome compared to controls (p<0.05); HR 0.90 (95% CI 0.83-0.98). CONCLUSIONS: Cardiac abnormalities were common in subjects with metabolic syndrome, predominantly affecting the left ventricular mass, diameter and left atrial volume. Early life style modifications are essential to prevent these complications.
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Sakthivadivel et al. (2023) conducted a cross-sectional in Metabolic syndrome (n=150). Metabolic syndrome vs. Controls was evaluated on Left ventricular diameter in systole (HR 1.29, 95% CI 1.13-1.46, p=<0.001). Metabolic syndrome was associated with significantly increased left ventricular diameter in systole compared to controls (HR 1.29; 95% CI 1.13-1.46; p<0.001).
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