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April 15, 2026CosmeticsOpen Access

Dihydrokaempferol Supports Epidermal Barrier, Dermal Repair, and Enhances Post-Procedure Recovery

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Authors

TOTaylor OswaldZSZixuan ShaoDZDaniel Zambrano

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Overview

Preclinical and clinical evaluation shows dihydrokaempferol improves skin recovery, suggesting its use in cosmetic procedures.

Key Points

  • This research aims to evaluate the effectiveness of dihydrokaempferol in supporting skin barrier recovery after cosmetic treatments.
  • Gene expression profiling in keratinocytes and dermal fibroblasts
  • Functional assays assessing antioxidant activity and fibroblast responses
  • Randomized, placebo-controlled, split-face clinical study after chemical peeling
  • DHK enhanced barrier-related gene expression
  • Reduced inflammation markers and improved extracellular matrix function
  • Significant improvements in skin quality observed in DHK-treated areas versus placebo

Cite This Study

Oswald et al. (2026) studied this question.

synapsesocial.com/papers/69df2c9ee4eeef8a2a6b1dbdhttps://doi.org/10.3390/cosmetics13020093
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