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April 16, 2026Journal of Herbmed PharmacologyOpen Access

Herbal-derived phytochemicals in hepatocellular carcinoma: A review of molecular targets and tumor microenvironment interventions

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Authors

JMJithin MathewNitte UniversitySAShakkeela Yusuf Erattil AhammedQassim UniversityGSGhada Ben SalahQassim University

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Overview

Narrative review explores herbal-derived phytochemicals affecting HCC, suggesting potential benefits for treatment enhancement.

Key Points

  • This review aims to explore the molecular targets of herbal-derived phytochemicals in hepatocellular carcinoma and their effects on the tumor microenvironment.
  • Analyzed existing literature on hepatocellular carcinoma and herbal interventions.
  • Examined the role of various phytochemicals and their effects on cancer pathways.
  • Discussed clinical implications and challenges of integrating natural compounds into standard therapy.
  • Natural compounds like curcumin and ginsenosides show promising anti-cancer effects.
  • Phytochemicals modulate pathways related to tumor growth and apoptosis.
  • Herbal extracts may enhance the efficacy of conventional cancer therapies despite variability and potential interactions.

Cite This Study

Mathew et al. (2026) studied this question.

synapsesocial.com/papers/69e07e582f7e8953b7cbf5e2https://doi.org/10.34172/jhp.2026.53276
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Current Therapeutic Strategies, Recent Advances and the Emerging Potential of Natural Products in Hepatocellular Carcinoma2026 · 2 citations
  2. 2Plant-Derived Secondary Metabolites Modulating Inflammation-Driven Pathways in Hepatocellular Carcinoma: Preclinical Insights2026
  3. 3Natural Products and Traditional Chinese Medicine in Hepatocellular Carcinoma: From Pharmacological Mechanisms to Clinical Translation2026
  4. 4Dietary Polyphenols and Selected Nutraceuticals in Hepatocellular Carcinoma: Mechanistic Insights, Translational Evidence, and Clinical Prospects2026
  5. 5The role of medicinal plants in the management of hepatocellular carcinoma and its metastasis2025