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June 3, 2026NutrientsOpen Access

Dietary Polyphenols and Selected Nutraceuticals in Hepatocellular Carcinoma: Mechanistic Insights, Translational Evidence, and Clinical Prospects

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Authors

FAFareeha ArshadAlfaisal UniversityAAArshiya AkbarAlfaisal UniversityRCRaja ChinnappanAlfaisal University

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Overview

Narrative review explores dietary polyphenols and nutraceuticals for HCC prevention, suggesting new adjunctive strategies.

Key Points

  • This review aims to explore the role of dietary polyphenols and nutraceuticals in the prevention and management of hepatocellular carcinoma (HCC).
  • Conducted a narrative review of epidemiological, experimental, and clinical literature.
  • Focused on molecular and cellular mechanisms related to dietary patterns and nutraceuticals for HCC.
  • Analyzed signaling pathways impacted by dietary compounds.
  • Dietary polyphenols and selected nutraceuticals influence multiple signaling pathways important in HCC, including NF-κB and PI3K/AKT.
  • Preclinical findings indicate potential enhancement of antitumor immunity and tumor sensitization to therapies.
  • Clinical application is hindered by challenges like limited bioavailability and a need for high-quality trials.

Cite This Study

Arshad et al. (2026) studied this question.

synapsesocial.com/papers/6a1fc4e4dee9eb8c0dce64fdhttps://doi.org/10.3390/nu18111783
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