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February 5, 2026Current Issues in Molecular BiologyOpen Access

Plant-Derived Secondary Metabolites Modulating Inflammation-Driven Pathways in Hepatocellular Carcinoma: Preclinical Insights

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Authors

SMSergio Arael Mendoza-CalderónBenito Juárez Autonomous University of OaxacaHLHolanda Isabel Cruz LuisInstituto Tecnológico de OaxacaLMLaura Pérez-Campos Mayoral

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Implication

Preclinical insights show plant compounds affect inflammation in hepatocellular carcinoma, suggesting therapeutic potential.

Key Points

  • The study aims to explore the role of plant-derived metabolites in altering inflammation-driven pathways in hepatocellular carcinoma.
  • Review of preclinical and experimental evidence on phytochemicals
  • Evaluation of key signaling pathways affected by these compounds
  • Discussion of challenges in clinical translation and recommendations for future studies
  • Phytochemicals modulate key signaling pathways like PI3K/AKT/mTOR and NF-κB
  • Induction of apoptosis and cell cycle arrest observed in multiple HCC models
  • Reduction in invasion and metastasis attributed to these metabolites

Cite This Study

Mendoza-Calderón et al. (2026) studied this question.

synapsesocial.com/papers/6984359ef1d9ada3c1fb4995https://doi.org/10.3390/cimb48020172
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Herbal-derived phytochemicals in hepatocellular carcinoma: A review of molecular targets and tumor microenvironment interventions2026
  2. 2Current Therapeutic Strategies, Recent Advances and the Emerging Potential of Natural Products in Hepatocellular Carcinoma2026 · 2 citations
  3. 3The role of medicinal plants in the management of hepatocellular carcinoma and its metastasis2025 · 1 citations
  4. 4Plant-derived natural products against hepatocellular carcinoma: chemical diversity, mechanisms of action, and organ-based classification2026
  5. 5Dietary Polyphenols and Selected Nutraceuticals in Hepatocellular Carcinoma: Mechanistic Insights, Translational Evidence, and Clinical Prospects2026