What question did this study set out to answer?

This review aims to explore natural products derived from plants that have potential anticancer activity against hepatocellular carcinoma.

Plant-derived natural products against hepatocellular carcinoma: chemical diversity, mechanisms of action, and organ-based classification

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Review identifies chemical diversity and mechanisms of natural products in combating hepatocellular carcinoma, highlighting therapeutic potential.

This review aims to explore natural products derived from plants that have potential anticancer activity against hepatocellular carcinoma.
Collected over 116 plant-derived natural products from sources like the Dictionary of Natural Products, PubMed, and Google Scholar.
Classified compounds by plant organ sources such as leaves, fruits, seeds, flowers, bark, and subterranean organs.
Reviewed mechanisms of action including proliferation inhibition and apoptosis induction.
Identified diverse secondary metabolites with anti-HCC activity.
Compiled a classification of over 116 compounds based on plant source.
Highlighted key mechanisms like modulating cell cycle and inhibiting telomerase activity.

Shady et al. (2026) studied this question.

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Review identifies chemical diversity and mechanisms of natural products in combating hepatocellular carcinoma, highlighting therapeutic potential.