The study reveals sex-specific genetic architectures and loci associated with late-life memory performance and decline.
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Demonstrated the heritable component of late-life memory is similar across sexes. Identified two genetic loci with a sex-interaction with baseline memory. Identified an X-chromosome locus associated with memory decline in females. Highlighted sex-specific candidate genes and pathways associated with memory. Revealed sex-specific shared genetic architecture between memory and complex traits.
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Sex-specific genetic loci may refine cognitive risk models; leaves open validation and clinical utility in prospective cohorts.
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Eissman et al. (2023) studied this question.
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