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April 19, 2026JMIR Research Protocols0 citationsOpen Access

Mechanisms of Referred Visceral Pain: Systematic Review Protocol on Neurogenic Inflammation

Inside-Out Mechanism of Referred Visceral Pain: Protocol for a Systematic Review of Cutaneous Neurogenic Inflammation in Preclinical Animal Models of Visceral Diseases

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Authors

EYEunMee YangBrigham and Women's HospitalDMDennis Munõz-VergaraBrigham and Women's HospitalAAAndrew C. AhnBrigham and Women's Hospital

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Overview

Systematic review synthesizes evidence on neurogenic inflammation and pain sensitivity in animal models of visceral diseases, suggesting critical insights for future research.

Key Points

  • This systematic review aims to compile evidence on cutaneous neurogenic inflammation and somatic pain sensitivity in preclinical models of visceral diseases.
  • Conduct systematic review following PRISMA-P guidelines.
  • Perform literature search in MEDLINE, Embase, and Web of Science.
  • Independently screen studies for eligibility using a predefined template.
  • Extract information regarding animal species, visceral disease models, and outcomes.
  • Assess study quality using the SYRCLE Risk of Bias tool.
  • As of August 2025, 536 records were identified, with 13 studies meeting eligibility criteria.
  • Data extraction and quality assessments are expected to be published in fall 2026.
  • Findings will summarize evidence on the relationship between neurogenic inflammation and referred pain.
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Cite This Study

Yang et al. (2026) studied this question.

synapsesocial.com/papers/69e47282010ef96374d8e90chttps://doi.org/10.2196/67852
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Also Consider

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  4. 4Role of Supraspinal Neuroinflammation in Chronic Pain After Experimental Spinal Cord Injury—A Systematic Review2026
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