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April 19, 2026JAMA Network OpenOpen Access

Maternal Circulating sFlt-1:PlGF Ratio and Stillbirth

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Authors

MLMi‐Sun LeeKEKi-Do EumDCDavid. C. Christiani

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Overview

This case-control study investigates the link between the sFlt-1:PlGF ratio and stillbirth risk in pregnant women, indicating potential clinical significance.

Key Points

  • To explore the relationship between maternal circulating sFlt-1:PlGF ratio and the risk of stillbirth using specific cutoff values.
  • Conducted as a case-control study in rural Bangladesh.
  • Included pregnant women with singleton pregnancies by 16 weeks’ gestation.
  • Matched cases of stillbirth with controls of live births in a 1:2 ratio.
  • Utilized Firth penalized logistic regression to analyze data with adjusted models.
  • An sFlt-1:PlGF ratio greater than 38 was significantly associated with a 13-fold increased odds of stillbirth.
  • Similar results were observed for the cutoff of 85 with an odds ratio of 12.95.
  • High positive predictive values were noted for both cutoffs, 88.9% at 38 and 85.7% at 85.
  • Negative predictive values were moderate, indicating low ratios do not effectively rule out stillbirth.

Cite This Study

Lee et al. (2026) studied this question.

synapsesocial.com/papers/69e473bd010ef96374d8f843https://doi.org/10.1001/jamanetworkopen.2026.7652
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Beyond Diagnostic Cut-Offs: Associations Between the sFlt-1/PlGF Ratio and Perinatal Outcomes in Low-Risk Term Pregnancies2026
  2. 2sFlt-1/PlGF Ratio as a Central Biomarker for Preeclampsia and Perinatal Outcomes: A Multisystem Retrospective Cohort Study2026 · 3 citations
  3. 3Impact of angiogenic factors and maternal endothelial dysfunction on pregnancy outcome.2026
  4. 4Angiogenic Biomarkers and Neonatal Outcomes in Suspected Preeclampsia: Retrospective Cohort Study2025 · 4 citations
  5. 5ANALYSING THE RELATIONSHIP BETWEEN SFLT-1/PLGF RATIO AND PREMATURE BIRTH2024