Decreased L-arginine-NO pathway activity is implicated in the impaired endothelium-dependent vasodilation seen in congestive heart failure.
May implicate L-arginine-NO pathway in heart failure endothelial dysfunction; leaves open therapeutic targeting.
A specific decrease in synthetic activity of the L-arginine-NO metabolic pathway contributes to decreased endothelium-dependent vasodilation in patients with congestive heart failure.
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Katz et al. (1999) studied this question.