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August 29, 1991New England Journal of Medicine420 citations

Evidence of a Selective Increase in Cardiac Sympathetic Activity in Patients with Sustained Ventricular Arrhythmias

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IMIan T. MeredithABA. BroughtonGJGarry Jennings

Structured PICO

Are major ventricular arrhythmias associated with sustained and selective cardiac sympathetic activation?

P
Population
Patients with sustained ventricular arrhythmias
O
Outcome
Cardiac sympathetic activitysurrogate

Sustained ventricular arrhythmias may be driven by reflex cardiac sympathetic activation secondary to depressed ventricular function.

Abstract

These results suggest that in some patients major ventricular arrhythmias are associated with and perhaps caused by sustained and selective cardiac sympathetic activation. We speculate that depressed ventricular function was present before the ventricular arrhythmia occurred, and that this resulted in reflex cardiac sympathetic activation, which in turn contributed to the genesis of the arrhythmia.

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Cite This Study

Meredith et al. (1991) studied this question.

synapsesocial.com/papers/69eff904bce9831ba4f73529https://doi.org/10.1056/nejm199108293250905
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