Why the study?
Does metoprolol reduce the number and complexity of premature ventricular complexes in patients after acute myocardial infarction?
Population
n=301 patients hospitalized for acute myocardial infarction, age <70 years, in sinus rhythm, without…
Comparison
Metoprolol 100 mg bid for up to 12 months vs Matching placebo
Design
RCT, Stratified before discharge according to age, size of infarction, and…
Follow-up
12 months
Authors
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Supports metoprolol post-MI to blunt PVC progression; reinforces beta-blocker benefits in arrhythmia management.
Does metoprolol reduce the number and complexity of premature ventricular complexes in patients after acute myocardial infarction?
Long-term treatment with metoprolol counteracts the natural increase in complexity and number of premature ventricular complexes during the first year after acute myocardial infarction.
Olsson et al. (1984) studied this question.
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