February 8, 2005Circulation
High Prevalence of Viral Genomes and Multiple Viral Infections in the Myocardium of Adults With “Idiopathic” Left Ventricular Dysfunction
Why the study?
What is the prevalence of viral genomes in the myocardium of adults with idiopathic left ventricular dysfunction?
Population
Adults with "idiopathic" systolic left ventricular dysfunction / dilated cardiomyopathy (DCM)
Design
Cross-sectional
Authors
Discussion
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Implication
Supports hypothesis-generating role of myocardial viral genomes in idiopathic LV dysfunction; leaves open causal inference and therapeutic implications.
Key Points
- The aim is to investigate the prevalence and role of viral genomes in adults with left ventricular dysfunction.
- Detection of viral genomes in endomyocardial biopsies (EMBs) from adults with systolic left ventricular dysfunction.
- Analysis of multiple viral infections in myocardial tissue.
- Viral genomes were frequently detected in EMBs of patients.
- Multiple viral infections were common, suggesting a significant role in the pathogenesis of dilated cardiomyopathy.
Structured PICO
What is the prevalence of viral genomes in the myocardium of adults with idiopathic left ventricular dysfunction?
P
Population
Adults with "idiopathic" systolic left ventricular dysfunction / dilated cardiomyopathy (DCM)
O
Outcome
Prevalence of viral genomes and multiple viral infections in endomyocardial biopsies (EMBs)surrogate
Viral genomes and multiple viral infections are highly prevalent in the myocardium of adults with idiopathic left ventricular dysfunction, suggesting a potential role in the pathogenesis of dilated cardiomyopathy.
Cite This Study
Kühl et al. (2005) studied this question.