August 1, 1992European Heart Journal

Inter-study variability in left ventricular mass measurement Comparison between M-mode echography and MRI

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Why the study?

Does MRI improve reproducibility of left ventricular mass measurement compared to M-mode echocardiography in echogenic patients without coronary artery disease?

Population

20 echogenic patients without evidence of coronary artery disease

Comparison

MRI vs M-mode echocardiography

Design

Cross-sectional, operators unaware of each other's results

Follow-up

within 4 days (interval between examinations)

Authors

PGPierre GermainImperial College London GRG RoulHôpitaux Universitaires de Strasbourg BKB. KastlerCentre National de la Recherche Scientifique

Discussion

Member takes

Implication

Supports MRI to reduce LV mass variability in trials; leaves open routine clinical replacement of echocardiography.

Structured PICO

Does MRI improve reproducibility of left ventricular mass measurement compared to M-mode echocardiography in echogenic patients without coronary artery disease?

Population

20 echogenic patients without evidence of coronary artery disease

Intervention

MRI (multislice 8 to 12 true, short-axis spin-echo imaging, 10 mm thick with 1 to 3 mm gap)

Comparator

M-mode echocardiography (Devereux's method, 'Penn-Cube' formula)

Outcome

Inter-study variability in left ventricular mass measurementsurrogate

MRI provides significantly higher reproducibility for left ventricular mass measurement compared to M-mode echocardiography, which can reduce required sample sizes in clinical trials.

Cite This Study

Germain et al. (1992) studied this question.

synapsesocial.com/papers/69effa50bce9831ba4f73aeb https://doi.org/10.1093/oxfordjournals.eurheartj.a060307

Topics

Hypertension management Echocardiography Cardiomyopathy Valvular heart disease

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