Key result
Recent smoking in STEMI patients undergoing primary PCI was associated with a higher adjusted 1-year risk of death or heart failure hospitalization (adjHR 1.49; 95% CI 1.09-2.02).
Why the study?
Smoking has been associated with favorable short-term outcomes after STEMI (the smoker's paradox), prompting investigation into whether smoking reduces infarct size, microvascular obstruction, or adverse outcomes.
Meta-Analysis (n=2,564)
Yes
Effect estimate: adjHR 1.49 (95% CI 1.09 to 2.02)
Absolute Event Rate: 3.3% vs 5.1%
p-value: p=0.009
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Should not change clinical practice in STEMI PCI patients; leaves open mechanisms for adjusted risk independent of infarct size.
Redfors et al. (2020) conducted a meta-analysis in ST-segment elevation myocardial infarction (STEMI) (n=2,564). Recent smoking vs. Nonsmokers was evaluated on 1-year death or heart failure hospitalization (adjHR 1.49, 95% CI 1.09 to 2.02, p=0.009). Recent smoking in STEMI patients undergoing primary PCI was associated with a higher adjusted 1-year risk of death or heart failure hospitalization (adjHR 1.49; 95% CI 1.09-2.02).
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