Geometry as a Confounder When Assessing Ventricular Systolic Function
Population
100 subjects with ejection fraction ranging from 16% to 72%, including a subset of 20 control subjects and…
Design
Other
Authors
Discussion
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Implication
Geometric factors may preserve EF despite impaired strain; leaves open whether strain better reflects systolic function than EF in preserved-EF cohorts.
Structured PICO
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Population
100 subjects with ejection fraction (EF) ranging from 16% to 72%, including a subset of 20 control subjects and 20 hypertrophic cardiomyopathy patients
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Intervention
Derivation of an analytical equation from an elliptical LV model and echocardiographic measurement of global longitudinal strain (GLS), global circumferential strain (GCS), wall thickness, and short-axis diameter
O
Outcome
Agreement between model-predicted EF and measured EFsurrogate
Geometric factors such as wall thickness and short-axis diameter can confound ejection fraction, making myocardial strain a more accurate reflection of true systolic function in patients with preserved EF.
Cite This Study
Stokke et al. (2017) studied this question.