Why the study?
Does prednisone and azathioprine improve left ventricular ejection fraction and histology in patients with active lymphocytic myocarditis and progressive heart failure?
Population
n=41 patients with a histological diagnosis of active lymphocytic myocarditis characterized by progressive…
Design
Cohort
Follow-up
1 year
Authors
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May support immunosuppression in autoantibody-positive, virus-negative lymphocytic myocarditis; hypothesis-generating and requires randomized confirmation.
Does prednisone and azathioprine improve left ventricular ejection fraction and histology in patients with active lymphocytic myocarditis and progressive heart failure?
Immunosuppressive therapy with prednisone and azathioprine is most effective in active lymphocytic myocarditis patients who possess circulating cardiac autoantibodies and lack myocardial viral genomes.
Frustaci et al. (2003) studied this question.
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