What question did this study set out to answer?

To examine the predictive value of glycated haemoglobin (HbA1c) concentration for all-cause, cardiovascular, and ischaemic heart disease mortality in men.

January 6, 2001BMJOpen Access

Glycated haemoglobin, diabetes, and mortality in men in Norfolk cohort of European Prospective Investigation of Cancer and Nutrition (EPIC-Norfolk)

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Authors

KKK.‐T. KhawUniversity of Cambridge

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Implication

Prospective cohort study shows elevated glycated haemoglobin continuously increases mortality in men, indicating cardiovascular risks extend well below diabetic thresholds.

Key Points

To examine the predictive value of glycated haemoglobin (HbA1c) concentration for all-cause, cardiovascular, and ischaemic heart disease mortality in men.
Prospective population cohort study assessing 4,662 men aged 45–79 years recruited between 1995 and 1997 and followed through December 1999.
Measured baseline HbA1c concentrations alongside conventional cardiovascular risk factors, including blood pressure, serum cholesterol, body mass index, and cigarette smoking.
Men with known diabetes showed higher mortality from all causes (relative risk [RR] 2.2), cardiovascular disease (RR 3.3), and ischaemic heart disease (RR 4.2; all P < 0.001) compared with men without diabetes.
Each 1% increase in HbA1c was associated with a 28% increase in all-cause mortality (P < 0.002); this excess risk remained significant (RR 1.46, P = 0.05) after excluding men with diagnosed diabetes, HbA1c ≥ 7%, or prior myocardial infarction or stroke.
Men with HbA1c concentrations between 5.0% and 6.9% accounted for 82% of the population excess mortality associated with HbA1c ≥ 5.0%, whereas men with diagnosed diabetes accounted for 18%.

Cite This Study

K.‐T. Khaw (2001) studied this question.

synapsesocial.com/papers/69f3ee02dc238f8197799573 https://doi.org/10.1136/bmj.322.7277.15

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Implication

Prospective cohort study shows elevated glycated haemoglobin continuously increases mortality in men, indicating cardiovascular risks extend well below diabetic thresholds.

Glycated haemoglobin, diabetes, and mortality in men in Norfolk cohort of European Prospective Investigation of Cancer and Nutrition (EPIC-Norfolk)

Discussion

Member takes

Implication

Key Points

Cite This Study

Glycated haemoglobin, diabetes, and mortality in men in Norfolk cohort of European Prospective Investigation of Cancer and Nutrition (EPIC-Norfolk)

Discussion

Member takes

Implication

Key Points

Cite This Study

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