Why the study?
Left atrial enlargement increases the risk of ablation failure in AF, so the study aimed to assess the influence of vein of Marshall ethanol infusion on persistent AF ablation in patients with severe LA enlargement.
Does vein of Marshall ethanol infusion improve ablation outcomes in patients with persistent atrial fibrillation and severe left atrial enlargement?
Does vein of Marshall ethanol infusion improve ablation outcomes in patients with persistent atrial fibrillation and severe left atrial enlargement?
Vein of Marshall ethanol infusion prior to RF ablation may improve ablation outcomes in patients with persistent AF and severe LA enlargement.
Answers are grounded in this paper and cite their sources.
May support VOM-EI in persistent AF with severe LA enlargement; leaves open need for randomized confirmation.
Background: Left atrial (LA) enlargement is a widely recognized factor that increases the risk of ablation failure in patients with atrial fibrillation (AF). This retrospective, observational study aimed to assess the influence of vein of Marshall (VOM) ethanol infusion (VOM-EI) on persistent atrial fibrillation (PsAF) ablation among patients with severe LA enlargement. Methods: In this research, 178 patients underwent the VOM-EI followed by the radiofrequency (RF) ablation procedure, which was based on circumferential pulmonary vein antrum (CPVA) ablation and linear ablation of the roof of the LA and the mitral isthmus (MI). In comparison, 83 patients only underwent the RF ablation procedure. Conclusion: The VOM-EI facilitated the left CPVA and the MI ablation and improved the ablation outcomes in patients with severe LA enlargement for treating PsAF.
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Luo et al. (2025) studied this question.
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