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May 6, 2026BiomoleculesOpen Access

Trihexyphenidyl Ameliorates Depression-like Behaviors in Adult Zebrafish Exposed to Chronic Unpredictable Stress, Consistent with Regulation of the MAPK Signaling Pathway

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Authors

SHSiqi HuYYYedong YaoSLSiyuan Li

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Overview

Experiment reveals Trihexyphenidyl reduces stress hormone levels in zebrafish, suggesting it may counteract chronic unpredictable stress effects.

Key Points

  • To investigate the effects of Trihexyphenidyl on depression-like behaviors in zebrafish exposed to chronic unpredictable stress.
  • Examined impact of THY on exploratory behavior and latency time in zebrafish under stress.
  • Analyzed tissue changes in optic tectum and Nissl bodies due to stress and THY treatment.
  • Conducted transcriptome sequencing analysis and network pharmacology to elucidate mechanisms.
  • THY significantly improved exploratory behaviors and reduced latency times in stressed zebrafish.
  • THY attenuated optic tectum thinning and Nissl bodies loss caused by chronic unpredictable stress.
  • THY lowered stress hormone levels and improved neurotransmitter content, easing neuroinflammation.

Cite This Study

Hu et al. (2026) studied this question.

synapsesocial.com/papers/69fa8e8904f884e66b530cdehttps://doi.org/10.3390/biom16050678
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Also Consider

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  1. 1Divergent neurobehavioral signatures of anxiety and depression: a multilevel comparative analysis in adult zebrafish2026
  2. 2Studying the Stress, Gene Expression, and Behavioral Changes Induced by Diazepam and Sertraline in a Zebrafish Model2026
  3. 3Neurobehavioral Effects of Two Distinct Anti-Inflammatory Drugs in a Two-Week Chronic Stress Model in Zebrafish2026
  4. 4Effect of Cryptotanshinone on BDNF/TrkB Pathway in Hippocampus of Chronic Stress-induced Depression Rats2024
  5. 5Tetramethylpyrazine Protects Against Depression-Like Behaviors through CREB/CRTC1 Signaling Pathway in a Depression Mouse Model2025