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May 7, 2026Prostate InternationalOpen Access

Context-Dependent Role of Digital Rectal Examination in a Contemporary Prostate Biopsy Cohort: Differential Predictive Value With and Without mpMRI

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Authors

HLHorst Emanuel Lagos-BeitzABAlexa Borbolla-RuizWGWolfgang González-Sosa

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Overview

Retrospective analysis highlights digital rectal examination's limited role in predicting cancer in biopsy cohorts, implying specific testing pathways influence results.

Key Points

  • To quantify the role of digital rectal examination in predicting clinically significant prostate cancer based on biopsies.
  • Retrospective analysis of 666 consecutive prostate biopsies at a single academic center.
  • Used multivariable logistic regression models to analyze factors influencing cancer prediction.
  • Assessed Discrimination using AUC and likelihood ratio tests.
  • csPCa prevalence was found to be 30.7% in patients undergoing biopsy.
  • DRE showed significant association with csPCa, although with modest discrimination gain.
  • Findings indicated that the role of DRE is context-dependent based on the presence of mpMRI.

Cite This Study

Lagos-Beitz et al. (2026) studied this question.

synapsesocial.com/papers/69fbe2f2164b5133a91a2308https://doi.org/10.1016/j.prnil.2026.04.006
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Addition of MRI or DRE to clinical data and risk prediction for clinically significant prostate cancer.2024
  2. 2Re-evaluating the role of digital rectal examination in prostate cancer diagnosis in the era of modern MRI2024
  3. 3Role of Multiparametric Magnetic Resonance Imaging and Targeted Biopsy in the Detection of Clinically Significant Prostate Cancer in Patients with Suspicious Digital Rectal Examination2024
  4. 4In the Era of mpMRI and PSMA PET/CT: Does Digital Rectal Examination Still Matter?2026
  5. 5PSA-density, DRE, and PI-RADS 5: potential surrogates for omitting biopsy?2024 · 6 citations