Why the study?
Does perivascular carotid collar placement induce rapid atherogenesis in apoE-/- and LDLr-/- mice?
Population
Apolipoprotein E-deficient (apoE-/-) and LDL receptor-deficient (LDLr-/-) mice
Design
Preclinical
Follow-up
6 weeks
Authors
Loading...
Establishes rapid site-controlled atherogenesis model in mice; leaves open clinical translation pending human studies.
Does perivascular carotid collar placement induce rapid atherogenesis in apoE-/- and LDLr-/- mice?
Perivascular carotid collar placement in apoE-/- and LDLr-/- mice on a high-cholesterol diet induces rapid, site-controlled atherogenesis, providing a useful model for atherosclerosis research.
Thüsen et al. (2001) studied this question.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: