Why the study?
Inflammatory activation with elevated cytokines and iNOS expression occurs in the skeletal muscles of patients with chronic heart failure, but the effects of regular exercise on these local parameters were unclear.
Does regular physical exercise training reduce local inflammatory parameters in the skeletal muscle of male patients with stable chronic heart failure?
Population
20 male patients with stable CHF
Comparison
Exercise training vs control
Design
Randomized controlled trial
Follow-up
Six months
Authors
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Supports anti-inflammatory effects of exercise in CHF; leaves open whether this drives outcome benefits and needs RCT confirmation.
Does regular physical exercise training reduce local inflammatory parameters in the skeletal muscle of male patients with stable chronic heart failure?
Exercise training reduces local inflammatory cytokine and iNOS expression in the skeletal muscle of patients with chronic heart failure, potentially attenuating catabolic wasting.
Gielen et al. (2003) studied this question.
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