Why the study?
Does IL-1 beta inhibit phospholamban gene expression in cultured neonatal rat cardiomyocytes?
Population
Primary cultures of neonatal rat cardiomyocytes
Comparison
Interleukin-1 beta 2 ng/mL, TNF-alpha, or both vs Control (untreated cells)
Design
Preclinical
Follow-up
20 hours
Authors
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IL-1β may impair contractility via phospholamban downregulation; hypothesis-generating for cytokine effects in inflammatory cardiomyopathy.
Does IL-1 beta inhibit phospholamban gene expression in cultured neonatal rat cardiomyocytes?
IL-1 beta significantly decreases phospholamban transcript and protein levels in cultured cardiomyocytes, suggesting a novel mechanism by which proinflammatory cytokines may depress cardiac contractility.
McTiernan et al. (1997) studied this question.
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