Is there a relationship between aortic valve degeneration and left ventricle function?

Aysel Akhundova; Murat Sünbül; Tarık Kıvrak; Fuad Samadov; Bülent Mutlu

doi:10.33678/cor.2022.143

September 1, 2023Cor et VasaOpen Access

Is there a relationship between aortic valve degeneration and left ventricle function?

View Full Paper

Ask AI

Bookmark

Share

Why the study?

To investigate the potential relationship between aortic valve degeneration and left ventricular function, and whether this relationship is reflected in biomarker levels.

Does degenerative aortic valve disease impair left ventricular global longitudinal strain and alter biomarker profiles compared to controls?

Key Points

Assess whether aortic valve degeneration impairs left ventricular function and affects circulating cardiovascular biomarker concentrations.
Enrolled 42 consecutive patients with degenerative aortic valve disease (sclerotic or stenotic) and 25 healthy controls.
Performed resting and post-exercise two-dimensional and speckle tracking echocardiography using semi-recumbent bicycle ergometry.
Measured circulating biomarkers, including galectin-3, high-sensitivity troponin T, C-reactive protein, and pro-BNP.
Left ventricular global longitudinal strain at peak exercise and recovery was significantly worse in patients with aortic valve degeneration than in controls.
Serum levels of C-reactive protein, high-sensitivity troponin T, and pro-BNP were significantly elevated in the degeneration group versus controls.
Multivariable linear regression identified C-reactive protein and peak-exercise mean transvalvular pressure gradients as independent predictors of left ventricular global longitudinal strain.

Structured PICO

Does degenerative aortic valve disease impair left ventricular global longitudinal strain and alter biomarker profiles compared to controls?

P

Population

42 consecutive patients with degenerative aortic valve (AV) disease (stenotic and sclerotic changes) and 25 control individuals

I

Intervention

Two-dimensional (2D) echocardiography and 2D speckle tracking echocardiography (STE) before and after semi-recumbent bicycle ergometry, along with biomarker assessment

C

Comparator

25 control individuals without degenerative AV disease

O

Outcome

Left ventricular global longitudinal strain (GLS) at peak exercise and during recoverysurrogate

Implication

Speckle tracking echocardiography during exercise can detect early subclinical left ventricular dysfunction in patients with aortic sclerosis despite normal conventional LV function.

Abstract

CĂl: CĂlem naĹĄĂ studie bylo zkoumat pĹĂpadnou souvislost mezi degeneracĂ aortĂĄlnĂ chlopnÄ (aortic valve, AV) a funkcĂ levĂŠ komory srdeÄnĂ (left ventricle, LV) a zda se takovĂĄ souvislost nĂĄslednÄ projevuje na hodnotĂĄch biomarkerĹŻ. Metody: Do studie bylo zaĹazeno 42 po sobÄ nĂĄsledujĂcĂch pacientĹŻ s degenerativnĂm postiĹženĂm AV a 25 kontrolnĂch jedincĹŻ. AortĂĄlnĂ chlopnÄ byly podle typu degenerace rozdÄleny na chlopnÄ se stenotickĂ˝mi a sklerotickĂ˝mi zmÄnami. U vĹĄech pacientĹŻ bylo pĹed bicyklovou ergometriĂ v pozici pololeĹže a nĂĄslednÄ po nĂ provedeno vyĹĄetĹenĂ metodami dvoudimenzionĂĄlnĂ (2D) jĂcnovĂŠ echokardiografie a 2D speckle tracking echokardiografie (STE). Sledovali jsme rovnÄĹž souvislost mezi sklerotickĂ˝m postiĹženĂm aorty a hodnoty biomarkerĹŻ, jako jsou galektin-3, troponin T stanovenĂ˝ metodou s vysokou citlivostĂ (high-sensitive [hs] troponin-T), C-reaktivnĂ protein (CRP) a pro-BNP. VĂ˝sledky: CelkovĂ˝ longitudinĂĄlnĂ strain (global longitudinal strain, GLS) LK byl pĹi maximĂĄlnĂ zĂĄtÄĹži a v dobÄ zotavovĂĄnĂ statisticky vĂ˝znamnÄ horĹĄĂ u pacientĹŻ s degenerovanou AV neĹž u kontrol. PĹi bazĂĄlnĂ zĂĄtÄĹži a maximĂĄlnĂ zĂĄtÄĹži i v obdobĂ zotavovĂĄnĂ byly u pacientĹŻ s degenerovanou AV - ve srovnĂĄnĂ s kontrolami - statisticky vĂ˝znamnÄ vĂce postiĹženĂŠ i rezervoĂĄrovĂĄ a konduitnĂ funkce levĂŠ sĂnÄ. Hodnoty CRP, hs-troponinu T a pro-BNP byly ve skupinĂĄch s degenerovanou AV statisticky vĂ˝znamnÄ vyĹĄĹĄĂ neĹž u kontrol. Hodnota LV GLS korelovala negativnÄ s hodnotami CRP a E/e' pĹi maximĂĄlnĂ zĂĄtÄĹži i s prĹŻmÄrnĂ˝mi transvalvulĂĄrnĂmi tlakovĂ˝mi gradienty u AV v klidu a pĹi maximĂĄlnĂ zĂĄtÄĹži. MultivariaÄnĂ lineĂĄrnĂ regresnĂ analĂ˝za prokĂĄzala, Ĺže hodnoty CRP a prĹŻmÄrnĂŠ transvalvulĂĄrnĂ tlakovĂŠ gradienty u AV pĹi maximĂĄlnĂ zĂĄtÄĹži jsou nezĂĄvislĂ˝mi prediktory LV GLS. ZĂĄvÄry: PĹes normĂĄlnĂ funkci LV nejenĹže dochĂĄzĂ u pacientĹŻ s aortĂĄlnĂ sklerĂłzou k vĂ˝znamnĂŠmu zhorĹĄenĂ LV GLS, tato zmÄna je vĂ˝raznÄjĹĄĂ pĹi maximĂĄlnĂ zĂĄtÄĹži. Z vĂ˝sledkĹŻ naĹĄĂ studie lze usuzovat, Ĺže STE pĹedstavuje spolehlivĂ˝ nĂĄstroj pro Äasnou detekci poruchy funkce LV pacientĹŻ s aortĂĄlnĂ sklerĂłzou. © 2023, ÄKS.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Akhundova et al. (2023) studied this question.

synapsesocial.com/papers/69fd564b5c6eda2188019120 https://doi.org/10.33678/cor.2022.143

View Full Paper

Ask AI

Bookmark

Share

Is there a relationship between aortic valve degeneration and left ventricle function?

Key Points

Structured PICO

Implication

Abstract

Discussion

Cite This Study

Is there a relationship between aortic valve degeneration and left ventricle function?

Key Points

Structured PICO

Implication

Abstract

Discussion

Cite This Study

Keep reading

More related papers

More from Cor et Vasa

Keep reading

More related papers

More from Cor et Vasa