Key result
Brachial flow-mediated vasodilatation showed a strong, significant negative correlation with the complexity of coronary artery disease based on the SYNTAX score (r = -0.787, p < 0.0001).
Why the study?
The reliability of brachial flow-mediated vasodilatation as a surrogate marker of coronary artery disease severity had not been clearly established.
Does brachial flow-mediated vasodilatation correlate with coronary artery disease severity as measured by the SYNTAX score?
Cross-Sectional (n=40)
No
Does brachial flow-mediated vasodilatation correlate with coronary artery disease severity as measured by the SYNTAX score?
Answers are grounded in this paper and cite their sources.
Brachial flow-mediated vasodilatation shows a strong negative correlation with the SYNTAX score, suggesting it can serve as a non-invasive predictor of coronary artery disease complexity.
CĂl: PĹestoĹže jiĹž byla identifikovĂĄna Ĺada rizikovĂ˝ch faktorĹŻ rozvoje aterosklerĂłzy, lze stĂĄle obtĂĹžnÄ pĹedpovĂdat, jak tyto faktory interagujĂ pĹi stanovovĂĄnĂ endotelovĂŠ funkce a rozvoje ischemickĂŠ choroby srdeÄnĂ (ICHS). NeinvazivnĂ vyĹĄetĹenĂ endotelovĂŠ funkce se Äasto provĂĄdĂ metodou endotel-dependentnĂ vazodilatace paĹžnĂ tepny (flow-mediated vasodilatation, FMD). Spolehlivost metody FMD jako zĂĄstupnĂŠho ukazatele zĂĄvaĹžnosti ICHS zatĂm nebyla jednoznaÄnÄ potvrzena. CĂlem tĂŠto studie bylo zjistit korelaci mezi vĂ˝sledky namÄĹenĂ˝mi metodou FMD a zĂĄvaĹžnostĂ ICHS s pouĹžitĂm skĂłre SYNTAX jako spolehlivÄjĹĄĂch a jednoduĹĄĹĄĂch diagnostickĂ˝ch nĂĄstrojĹŻ. Metoda: NaĹĄe studie mÄla prĹŻĹezovĂŠ uspoĹĂĄdĂĄnĂ s nenĂĄhodnĂ˝m ĂşÄelovĂ˝m vzorkovĂĄnĂm. Ădaje od pacientĹŻ po koronarografickĂŠm vyĹĄetĹenĂ jsme shromaĹžÄovali v obdobĂ od ĹĂjna do prosince 2015. ZĂĄvaĹžnost ICHS se vypoÄĂtĂĄvala pomocĂ skĂłre SYNTAX. EndotelovĂĄ funkce se hodnotila metodou FMD paĹžnĂ tepny s pouĹžitĂm dopplerovskĂŠho ultrazvuku. Korelace mezi hodnotami FMD a skĂłre SYNTAX se zjiĹĄĹĽovala pomocĂ Pearsononova korelaÄnĂho testu. VĂ˝sledky: Do studie jsme zaĹadili 40 pacientĹŻ s ICHS pĹijatĂ˝ch na kliniku kardiologie nemocnice Dr. Soetomo General Hospital. PrĹŻmÄrnĂ˝ vÄk pacientĹŻ byl 55,38 ± 9,27 roku, 85 % (n = 34) z nich byli muĹži, 67 % (n = 27) mÄlo hypertenzi, 80 % (n = 32) framinghamskĂŠ skĂłre vysokĂŠho rizika a u 27,5 % (n = 21) bylo podle klasifikace SCORE pĹĂtomno stĹednÄ vysokĂŠ riziko. PĹed katetrizacĂ byla stanovena diagnĂłza postakutnĂho koronĂĄrnĂho syndromu u 65 % (n = 27) pacientĹŻ s prĹŻmÄrnou hodnotou skĂłre SYNTAX 33,21 ± 10,86. Byla zjiĹĄtÄna tÄsnĂĄ, negativnĂ a statisticky vĂ˝znamnĂĄ korelace mezi hodnotou FMD a skĂłre SYNTAX (r = -0,787 a p < 0,0001). ÄĂm je hodnota FMD niŞťĂ, tĂm je ICHS zĂĄvaĹžnÄjĹĄĂ. ZĂĄvÄr: PĹi pouĹžitĂ skĂłre SYNTAX vykazuje metoda FMD tÄsnou a negativnĂ korelaci se zĂĄvaĹžnostĂ ICHS. NiŞťà hodnota FMD predikuje zĂĄvaĹžnÄjĹĄĂ ICHS. © 2021, ÄKS.
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Sakulat et al. (2021) conducted a cross-sectional in Coronary artery disease (n=40). Brachial flow-mediated vasodilatation (FMD) was evaluated on Correlation between FMD and SYNTAX score (r = -0.787, p=<0.0001). Brachial flow-mediated vasodilatation showed a strong, significant negative correlation with the complexity of coronary artery disease based on the SYNTAX score (r = -0.787, p < 0.0001).
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