May 18, 2010Diabetes181 citationsOpen Access
The Association of Hemoglobin A1c With Incident Heart Failure Among People Without Diabetes: The Atherosclerosis Risk in Communities Study
Structured PICO
Does elevated HbA1c increase the risk of incident heart failure in individuals without diabetes?
P
Population
11,057 middle-aged participants of the Atherosclerosis Risk in Communities (ARIC) Study without heart failure or diabetes at baseline
I
Intervention
Elevated HbA1c levels (categories: 5.5-5.9% and 6.0-6.4%) and elevated fasting glucose levels
C
Comparator
Reference HbA1c category (5.0-5.4%) and reference fasting glucose category (90-99 mg/dl)
O
Outcome
Incident heart failure hospitalization or deaths (International Classification of Disease, 9th/10th Revision, 428/I50)hard clinical
Elevated HbA1c, but not fasting glucose, is independently associated with an increased risk of incident heart failure in middle-aged individuals without diabetes.
Abstract
OBJECTIVE: This study sought to investigate an association of HbA1c (A1C) with incident heart failure among individuals without diabetes and compare it to fasting glucose. RESEARCH DESIGN AND METHODS: We studied 11,057 participants of the Atherosclerosis Risk in Communities (ARIC) Study without heart failure or diabetes at baseline and estimated hazard ratios of incident heart failure by categories of A1C ( or =5.5-6.0%) was associated with incident heart failure in a middle-aged population without diabetes, suggesting that chronic hyperglycemia prior to the development of diabetes contributes to development of heart failure.