Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
May 8, 2026British Journal Of Nutrition

Association Between Dietary Inflammatory Index and Cardiometabolic Risk in Women with Polycystic Ovary Syndrome

View Full Paper
Ask AI
Bookmark
Share

Key result

Higher Dietary Inflammatory Index scores are linked to worse cardiometabolic markers in women with PCOS.

  • P=0.015
  • n=77

Why the study?

Is a higher Dietary Inflammatory Index associated with increased cardiometabolic risk in women with Polycystic Ovary Syndrome?

Population

Women with PCOS and healthy controls

Comparison

Women with PCOS vs healthy controls across DII levels

Authors

EUElif UluğSASeren AksunAPA. Pinar

Discussion

Loading...

Member takes

Overview

PCOS cardiometabolic risk persists independent of dietary inflammation; leaves open non-dietary mechanisms for hypothesis-generating research.

Key Points

  • This study aims to examine the relationship between dietary inflammatory index and cardiometabolic risk factors in women with PCOS.
  • Clinical, hormonal, and biochemical assessments conducted in women with PCOS and healthy controls.
  • Dietary intake assessed via validated food frequency questionnaire to calculate dietary inflammatory index (DII).
  • Statistical analyses performed using ANCOVA to account for DII's effect on cardiometabolic risk markers.
  • Women with PCOS had higher fasting insulin and adverse lipid profiles compared to controls (p<0.05).
  • DII was positively associated with higher waist-to-hip ratio and elevated triglycerides (p<0.01).
  • Higher DII scores correlated with poorer cardiometabolic health indices in the PCOS group.

Study Design

Type

Case-Control (n=77)

Multicenter

No

Structured PICO

Is a higher Dietary Inflammatory Index associated with increased cardiometabolic risk in women with Polycystic Ovary Syndrome?

P
Population
Women with Polycystic Ovary Syndrome (PCOS) and healthy controls
I
Intervention
Dietary Inflammatory Index (DII) assessment
C
Comparator
Healthy controls
O
Outcome
Cardiometabolic risk markers including fasting insulin, HOMA-IR, and lipid profilesurrogate

Main Result

p-value: p=0.015

A pro-inflammatory dietary pattern is associated with unfavorable cardiometabolic risk factors in women with PCOS, supporting the potential benefit of anti-inflammatory dietary strategies.

Limitations

  • Case-control design limits the ability to infer causality
  • Small sample size may limit power to detect small effect sizes in complex regression models
  • Dietary intake assessment based on self-reported food frequency questionnaires is prone to recall bias and inaccuracies
  • DII does not account for food preparation methods, nutrient bioavailability, or interactions between nutrients

Cite This Study

Uluğ et al. (2026) conducted a case-control in Polycystic Ovary Syndrome (PCOS) (n=77). Dietary Inflammatory Index (DII) vs. Healthy controls was evaluated on Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) (p=0.015). Higher Dietary Inflammatory Index scores were positively associated with adverse cardiometabolic markers, including fasting serum glucose (β = 0.429, p = 0.001) and waist-to-hip ratio (β = 0.393, p = 0.001), in women with Polycystic Ovary Syndrome.

synapsesocial.com/papers/69fd7ef7bfa21ec5bbf07472https://doi.org/10.1017/s0007114526107405
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cross-sectional study of the relationship between dietary inflammatory index and inflammatory hormonal and metabolic profiles in polycystic ovary syndrome2025
  2. 2Association between Dietary Inflammatory Index (DII) and the Risk of Polycystic Ovary Syndrome: A Case-Control Study2024 · 3 citations
  3. 3Association between dietary inflammatory index, empirical dietary inflammatory patterns, dietary and lifestyle inflammation scores, and polycystic ovary syndrome: a case-control study2025 · 4 citations
  4. 4Association of Dietary Inflammatory Index with Inflammatory Markers like C-Reactive Protein and Interleukin-6 in Women with and without Polycystic Ovarian Syndrome: A Comparative Case-Control Study2023 · 1 citations
  5. 5Assessment of Dietary Inflammatory Index and Antioxidant Capacity in Women with Polycystic Ovary Syndrome: A Case–Control Study2026