Endothelins and Endothelin Receptor Antagonists
Key result
Endothelin antagonists show therapeutic promise across cardiovascular diseases by targeting endothelin-1.
Why the study?
Endothelin-1 plays a major role in cardiovascular diseases through pressure-independent mechanisms, and endothelin receptor antagonists are promising therapeutic agents.
Design
Review of endothelin system and receptor antagonists
Authors
Discussion
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Member takes
Implication
ET-1 antagonists should not yet enter routine practice; leaves open their role pending dedicated outcome trials.
PICO
P
Population
Cardiovascular diseases
I
Intervention / Comparator
Endothelin receptor antagonists
Endothelin-1 is a key mediator in various cardiovascular diseases, making endothelin receptor antagonists a promising therapeutic target.
Cite This Study
Lüscher et al. (2000) conducted a review in Cardiovascular diseases. Endothelin receptor antagonists was evaluated. Endothelin-1 plays a major role in cardiovascular diseases, making endothelin antagonists promising new agents for treatment.