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October 14, 1988Science

Sarafotoxin, a Novel Vasoconstrictor Peptide: Phosphoinositide Hydrolysis in Rat Heart and Brain

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Population

Rat atrial and brain membranes

Comparison

Sarafotoxins vs Blockers or activators of known receptors and…

Design

Preclinical

Authors

YKYoel KloogTel Aviv UniversityIAI. AmbarTel Aviv UniversityMSMordechai SokolovskyTel Aviv University

Discussion

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Implication

Hypothesis-generating for a novel receptor in vasoconstriction; leaves open translation to human cardiovascular physiology.

Structured PICO

P
Population
Rat atrial and brain membranes
I
Intervention
Sarafotoxins (21-residue cardiotoxic peptides from snake venom)
C
Comparator
Blockers or activators of known receptors and ion channels
O
Outcome
Phosphoinositide hydrolysis and receptor bindingsurrogate

Sarafotoxins induce coronary vasoconstriction by activating phosphoinositide hydrolysis via a potentially novel receptor, sharing high sequence homology with mammalian endothelin.

Cite This Study

Kloog et al. (1988) studied this question.

synapsesocial.com/papers/6a70c8d05671bbf00bc2c56bhttps://doi.org/10.1126/science.2845579
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Also Consider

Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Alpha 1-adrenergic and muscarinic cholinergic stimulation of phosphoinositide hydrolysis in adult rat cardiomyocytes.1985 · 296 citations
  2. 2Lithium amplifies agonist-dependent phosphatidylinositol responses in brain and salivary glands1982 · 2,146 citations