Key result
Sarafotoxin 6c reduces VF incidence by ~78% during ischemia in rats.
Why the study?
Does sarafotoxin 6c protect against ischaemia-induced cardiac arrhythmias in rat models?
Does sarafotoxin 6c protect against ischaemia-induced cardiac arrhythmias in rat models?
Absolute Event Rate: 13% vs 59%
Sarafotoxin 6c, an ETB-receptor agonist, demonstrates direct antiarrhythmic effects against ischaemia-induced arrhythmias in rat hearts.
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ETB agonism may protect against ischaemic arrhythmias in rats; leaves open translation to human cardioprotection.
Crockett et al. (2000) studied Ischaemia-induced cardiac arrhythmias. Sarafotoxin 6c (S6c) vs. Vehicle was evaluated on Incidence of ventricular fibrillation (VF) in vivo. In vivo administration of sarafotoxin 6c significantly reduced the incidence of ventricular fibrillation from 59% to 13% during ischaemia in rats.
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