Key result
After ischemia/reperfusion in isolated rat hearts, coronary constrictor effects of endothelins were enhanced and vasodilator effects inhibited, likely due to receptor upregulation and vasodilator loss.
Why the study?
Does ischemia/reperfusion alter the coronary vascular response to endothelins in isolated rat hearts?
Does ischemia/reperfusion alter the coronary vascular response to endothelins in isolated rat hearts?
Ischemia/reperfusion enhances the coronary constrictor effects of endothelins in rat hearts, likely due to a combination of ETA receptor upregulation and loss of ETB-mediated vasodilatation.
No takes yet. Share an insight, caveat, or question.
ETB loss may amplify post-I/R ET-1 constriction in rat hearts; leaves open clinical relevance and therapeutic targeting.
Thompson et al. (1995) studied myocardial ischemia/reperfusion. Endothelins-1, -2, -3 and Sarafotoxin 6c vs. control hearts was evaluated on coronary constrictor and vasodilator responses. After ischemia/reperfusion in isolated rat hearts, coronary constrictor effects of endothelins were enhanced and vasodilator effects inhibited, likely due to receptor upregulation and vasodilator loss.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: