June 1, 1990Proceedings of the National Academy of SciencesOpen Access

Endothelins are more sensitive than sarafotoxins to neutral endopeptidase: possible physiological significance.

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Why the study?

Does neutral endopeptidase degrade endothelins more rapidly than sarafotoxins?

Population

In vitro model using bovine kidney neutral endopeptidase (NEP), endothelins (ETs), and sarafotoxins (SRTXs)

Comparison

Incubation with neutral endopeptidase (NEP) vs Sarafotoxins (SRTXs) vs Endothelins (ETs)

Design

Preclinical

Authors

MSM SkolovskyTel Aviv University RGRonit GalronTel Aviv University YKYoel KloogTel Aviv University

Discussion

Member takes

Implication

May explain lower ET toxicity via faster NEP degradation; leaves open translation to human cardiovascular regulation.

Structured PICO

Does neutral endopeptidase degrade endothelins more rapidly than sarafotoxins?

Population

In vitro model using bovine kidney neutral endopeptidase (NEP), endothelins (ETs), and sarafotoxins (SRTXs)

Intervention

Incubation with neutral endopeptidase (NEP)

Comparator

Sarafotoxins (SRTXs) vs Endothelins (ETs)

Outcome

Degradation rate (half-time) and biochemical activitysurrogate

Endothelins are degraded more rapidly than sarafotoxins by neutral endopeptidase, suggesting a physiological mechanism for ET inactivation and explaining their lower toxicity compared to SRTXs.

Cite This Study

Skolovsky et al. (1990) studied this question.

synapsesocial.com/papers/6a8386e145d6ebe77211ab15 https://doi.org/10.1073/pnas.87.12.4702

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Ask AI

Bookmark

Endothelins are more sensitive than sarafotoxins to neutral endopeptidase: possible physiological significance.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Endothelins are more sensitive than sarafotoxins to neutral endopeptidase: possible physiological significance.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider