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May 7, 2026HaematologicaOpen Access

Lessons of nature from trisomy-8 myeloid neoplasia: the riddle of oncogenic clonal drives

Hussein Awada Arda Durmaz Luca Guarnera Zachary Brady Yasuo Kubota Serhan Ünlü Carmelo Gurnari Carlos Bravo‐Pérez Hassan Awada Torsten Haferlach Jaroslaw P. Maciejewski Valeria Visconte

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Key Points

The research aims to understand the role of trisomy-8 in myeloid neoplasia and its associated oncogenic processes.
Analysis of genetic mutations linked to trisomy-8 in myeloid neoplasia cases.
Examination of oncogenic clonal drives contributing to disease progression.
Investigation of therapeutic implications based on findings.
Identification of key oncogenes associated with trisomy-8.
Discovery of distinct clonal evolution patterns in affected individuals.
Findings suggest new avenues for targeted treatment strategies.

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Implication

Investigates genetic factors in myeloid neoplasia, highlighting implications for cancer treatment.

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Cite This Study

Awada et al. (2026) studied this question.

synapsesocial.com/papers/69fecfafb9154b0b82876aac https://doi.org/10.3324/haematol.2026.300822

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Cumulative disruption of regulatory genes precedes whole-chromosome gains in acute myeloid leukemiaMeta-Analysis · 2026
2Abstract B074: Clonal decomposition and DNA replication states defined by scaled single-cell DNA and RNA sequencing suggest clone-specific therapeutic vulnerabilities in neuroblastoma2024
3Supplementary Figures S1-S4 from Trisomy 8 Defines a Distinct Subtype of Myeloproliferative Neoplasms Driven by the MYC–Alarmin Axis2024
4Supplementary Figures S1-S4 from Trisomy 8 Defines a Distinct Subtype of Myeloproliferative Neoplasms Driven by the MYC–Alarmin Axis2024
5Trisomy 8 alters chromatin conformations and activates Y chromosome genes in stem cells to drive a pre-leukemic stateOriginal Research · 2026 · 1 citations

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Clonal Metamorphosis: Deconstructing MPN Evolution with Single-Cell and Spatial Multi-Omics2026
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Outcomes and prognostic impact of trisomy 8 in acute myeloid leukemia patients treated with intensive chemotherapy2025

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