What question did this study set out to answer?

To establish cow-level critical thresholds for serum nonesterified fatty acids (NEFA) and beta-hydroxybutyrate (BHBA) and quantify their associations with clinical periparturient diseases within 30 days in milk.

February 1, 2010Journal of Dairy ScienceOpen Access

Evaluation of nonesterified fatty acids and β-hydroxybutyrate in transition dairy cattle in the northeastern United States: Critical thresholds for prediction of clinical diseases

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Authors

POP.A. OspinaCornell University DND.V. NydamThe Nature Conservancy TSTracy StokolCornell University

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Implication

Prospective cohort study identifies critical NEFA and BHBA thresholds in transition dairy cows, highlighting postpartum NEFA as the strongest predictor of clinical diseases within 30 days in milk.

Key Points

To establish cow-level critical thresholds for serum nonesterified fatty acids (NEFA) and beta-hydroxybutyrate (BHBA) and quantify their associations with clinical periparturient diseases within 30 days in milk.
Conducted a prospective cohort study across 100 freestall, total mixed ration-fed dairy herds in the northeastern United States.
Sampled approximately 15 prepartum and 15 postpartum transition cows per herd, collecting 2,758 total blood samples to measure prepartum NEFA as well as postpartum NEFA and BHBA.
Evaluated critical diagnostic thresholds via receiver operating characteristic analysis and modeled disease risk ratios (RR) using multivariable regression accounting for herd-level clustering.
Identified critical thresholds predicting any of the targeted diseases at 0.29 mEq/L for prepartum NEFA, 0.57 mEq/L for postpartum NEFA, and 10 mg/dL for postpartum BHBA.
Postpartum NEFA was the strongest predictor of clinical disease, yielding risk ratios exceeding 1.8 across all outcomes and a notable peak for displaced abomasum (RR = 9.7; 95% CI: 4.2 to 22.4).
Postpartum BHBA concentrations above the threshold also significantly increased disease risk across all outcomes (RR > 2.3), including displaced abomasum (RR = 6.9; 95% CI: 3.7 to 12.9).

Cite This Study

Ospina et al. (2010) studied this question.

synapsesocial.com/papers/69ff8f65e4618ba4162d8227 https://doi.org/10.3168/jds.2009-2277

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Implication

Prospective cohort study identifies critical NEFA and BHBA thresholds in transition dairy cows, highlighting postpartum NEFA as the strongest predictor of clinical diseases within 30 days in milk.

Evaluation of nonesterified fatty acids and β-hydroxybutyrate in transition dairy cattle in the northeastern United States: Critical thresholds for prediction of clinical diseases

Discussion

Member takes

Implication

Key Points

Cite This Study

Evaluation of nonesterified fatty acids and β-hydroxybutyrate in transition dairy cattle in the northeastern United States: Critical thresholds for prediction of clinical diseases

Discussion

Member takes

Implication

Key Points

Cite This Study

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