What question did this study set out to answer?

This research aims to identify predictors of transplant-free survival in patients with giant cell myocarditis.

July 13, 2016European Journal of Heart Failure

Long-Term Outcome and its Predictors in Giant Cell Myocarditis

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Population

46 patients with giant cell myocarditis (31 women, mean age 51 ± 12 years)

Design

Cohort

Follow-up

median 11 months

Authors

KEKaj EkströmUniversity of Helsinki JLJukka LehtonenHeart Failure & Transplant RKRiina KandolinUniversity of Helsinki

Discussion

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Implication

Supports risk stratification in giant cell myocarditis; hypothesis-generating and requires prospective validation before guiding care.

Key Points

This research aims to identify predictors of transplant-free survival in patients with giant cell myocarditis.
Analyzed clinical data of 46 patients with giant cell myocarditis from 1991 to 2015.
Followed patients for cardiac death or transplantation, focusing on post-diagnosis outcomes.
Evaluated associations of patient characteristics, lab results, and myocardial histology with transplant-free survival.
5-year transplant-free survival estimated at 42% (95% CI 35-48%).
Hazard ratio for death/transplantation was 0.87 per +5% difference in LVEF and 1.06 per +1000 ng/L difference in NT-proBNP.
Presence of moderate or severe necrosis/fibrosis predicted a hazard ratio of 7.17 for poor outcomes.

Structured PICO

Population

46 patients with giant cell myocarditis (31 women, mean age 51 ± 12 years)

Outcome

Transplant-free survival (occurrence of cardiac death or transplantation)composite

In giant cell myocarditis, 5-year transplant-free survival is 42%, with markers of myocyte injury (troponin, NT-proBNP, biopsy necrosis/fibrosis) and cardiac dysfunction (LVEF) predicting worse outcomes.

Cite This Study

Ekström et al. (2016) studied this question.

synapsesocial.com/papers/69ffcccfd1d8b50f8e9a138f https://doi.org/10.1002/ejhf.606

Topics

Heart transplantation Cardiac device therapy Ventricular arrhythmias Myocarditis Heart failure

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Long-Term Outcome and its Predictors in Giant Cell Myocarditis

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Long-Term Outcome and its Predictors in Giant Cell Myocarditis

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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