What question did this study set out to answer?

To determine whether chronic hyperglycemia independently attenuates coronary collateral development and impairs the angiogenic properties of myocardial interstitial fluid via matrix metalloproteinase and angiostatin induction.

May 11, 2004Circulation

Chronic Hyperglycemia Attenuates Coronary Collateral Development and Impairs Proliferative Properties of Myocardial Interstitial Fluid by Production of Angiostatin

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To determine whether chronic hyperglycemia independently attenuates coronary collateral development and impairs the angiogenic properties of myocardial interstitial fluid via matrix metalloproteinase and angiostatin induction.
Chronically instrumented dogs were randomly assigned to receive normal saline (control; n=9) or 70% dextrose to achieve blood glucose levels of 350 to 400 mg/dL for 8 h/d (hyperglycemia; n=7) during repetitive coronary occlusions (1/h; 8/d for 21 days), or sham occlusion (n=9).
Investigators measured collateral blood flow, postocclusive peak reactive hyperemic responses, myocardial interstitial fluid-induced endothelial tube formation, and MMP-9/angiostatin expression.
Collateral perfusion increased to 41±11% and 49±6% of normal zone flow in controls on days 14 and 21 (P<0.05), but remained unchanged at 12±3% in hyperglycemic dogs and 13±3% in sham dogs.
Postocclusive peak reactive hyperemia decreased significantly in control dogs (16±1 to 10±1 Hz × 10² from day 1 to 21) but failed to decrease in hyperglycemic (17±2 to 20±2) or sham (17±2 to 16±1) dogs.
Hyperglycemic myocardial interstitial fluid failed to induce endothelial cell tube formation, an impairment reversed by anti-angiostatin antibodies and accompanied by increased MMP-9 activity and angiostatin expression.

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Implication

Randomized animal study demonstrates that chronic hyperglycemia abolishes coronary collateral growth in dogs, indicating angiostatin mediates vascular impairment.

Cite This Study

Weihrauch et al. (2004) studied this question.

synapsesocial.com/papers/6a005f10da5c1eb07f2da484 https://doi.org/10.1161/01.cir.0000129225.67353.1f

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Implication

Randomized animal study demonstrates that chronic hyperglycemia abolishes coronary collateral growth in dogs, indicating angiostatin mediates vascular impairment.

Chronic Hyperglycemia Attenuates Coronary Collateral Development and Impairs Proliferative Properties of Myocardial Interstitial Fluid by Production of Angiostatin

Key Points

Discussion

Implication

Cite This Study

Chronic Hyperglycemia Attenuates Coronary Collateral Development and Impairs Proliferative Properties of Myocardial Interstitial Fluid by Production of Angiostatin

Key Points

Discussion

Implication

Cite This Study

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