January 1, 2014Journal of Immunology ResearchOpen Access

Analysis of Autoantibodies to 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase Using Different Technologies

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Why the study?

Do different assay technologies (ELISA, CIA, laser bead) show agreement in detecting anti-HMGCR antibodies in patients with statin-associated myopathies?

Structured PICO

Do different assay technologies (ELISA, CIA, laser bead) show agreement in detecting anti-HMGCR antibodies in patients with statin-associated myopathies?

Population

20 myositis patients positive for anti-HMGCR antibodies (mean age 54.4 years, 16/20 female, 18/20 with necrotizing myopathy, 9/20 on statin), 20 negative controls, and 824 additional controls.

Intervention

QUANTA Lite HMGCR ELISA and QUANTA Flash HMGCR CIA assays

Comparator

Research addressable laser bead assay

Outcome

Qualitative agreement and correlation between assays for detecting anti-HMGCR antibodiessurrogate

Different assay technologies for detecting anti-HMGCR antibodies in statin-associated necrotizing myopathy show excellent agreement and high specificity.

Authors

LMLucile MussetAssistance Publique – Hôpitaux de Paris MMMakoto MiyaraSorbonne Université OBOlivier BenvénisteInserm

Discussion

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Implication

Supports interchangeable assay use for anti-HMGCR detection; leaves open prospective validation in broader cohorts.

Cite This Study

Musset et al. (2014) studied this question.

synapsesocial.com/papers/6a011e087ac91c5d2a2d73ea https://doi.org/10.1155/2014/405956

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